Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
A 10 week clinical study was conducted on 25 subjects having the prerequisites of moderate to severe hyperpigmentation as well as other cutaneous aging indicators.The study focus was on a one time, nightly applied test product that contained retinol 0.5%, niacinamide 4.4%, resveratrol 1%, and hexylresorcinol 1.1% in a moisturizing base. During the study, subjects were provided with a controlled skin care regimen as well. The results show that the test product is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen.
A novel skin brightening topical technology
This study investigates a topical facial test formulation containing hexylresorcinol, silymarin, 20% vitamin C, and 5% vitamin E in a proprietary anhydrous vehicle by clinical means as well as in skin explants for UVB photoprotective effects. The clinical study was conducted on 42 female subjects who were evaluated by a dermatologist investigator for brightening, evenness, fine lines, wrinkles, and global appearance. The results show the test formulation was effective clinically in showing skin brightness improvement and also effective in decreasing UVB-induced photodamage in skin explants.
Professional-Grade TCA-Lactic Acid Chemical Peel: Elucidating Mode of Action to Treat Photoaging and Hyperpigmentation
This research was conducted in order to understand the mode of action of a commercial professional chemical peel with the purpose of treating hyperpigmented and photoaged skin. The in-vitro experiments show that the peel prevents the enzymes behind the degradation of collagen, elastin and producing melanin pigment. It was also found that there is a synergistic effect between trichloroacetic acid (TCA) and lactic acid. 3D human skin equivalents and ex-vivo human biopsy were also used to test a variety of parameters in order to confirm the in-vitro results for collagen and elastin.
Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging
A topical hyaluronic acid facial serum used twice daily in conjunction with sunscreen was tested clinically on forty females. The dermatologist investigator evaluated smoothness, plumping, hydration, fine lines/wrinkles, and global appearance. Corneometer® measurements and photography were performed. Additionally, facial swabbing was conducted in order to confirm an increase in topical HA. It was concluded that a topical HA facial serum formulation provides excellent skin hydration.
Facial Mask Moisturization Study: Case Report
A Hyaluronic Acid Overnight Mask, a combination of HA of varying molecular weights, was tested in-vivo immediately after use and at the eight hour time point in order to show the increase in moisture in human skin and also the maintaining of moisture for an eight hour period. The conclusions of this study were based on standard Corneometer® measurements as well as Corneometer® facial mapping.